Table 2.

Parenchymal architecture

Parameter	WT	DiNOS	Sftpd−/−
Body weight, g	31.5 ± 1.9	33.0 ± 1.6	31.0 ± 5.0
V(lung), cm3	1.21 ± 0.17	1.29 ± 0.16	1.36 ± 0.17
V(par, lung), cm3	1.05 ± 0.15	1.13 ± 0.14	1.13 ± 0.11
V(alvair,lung), cm3	0.59 ± 0.09	0.66 ± 0.10	0.61 ± 0.10
V(ductair,lung), cm3	0.32 ± 0.05	0.32 ± 0.05	0.30 ± 0.02
V(sep,lung), cm3	0.14 ± 0.04	0.15 ± 0.02	0.21 ± 0.04*§
S(alvepi, lung), cm2	775.3 ± 64.4	685.1± 39.8	625.2 ± 88.2*
Lm(air), μm	46.8 ± 5.2	57.7 ± 9.5	58.8 ± 7.7

Values are given as means ± SD of n = 4 (Sftpd^−/−) or n = 5 (DiNOS and WT) mice/group. V, volume; S, surface area; L_m(air), mean linear intercept length of distal airspaces; Par, parenchyma; alvair, alveolar airspace; ductair, ductal airspace; sep, septal wall tissue; alvepi, alveolar epithelium.

^*P < 0.05 vs. WT,

^§P < 0.05 vs. DiNOS; statistically significant differences between groups.