Table 2.

Classification of genes identified in Cmah-functional analysis.

Biological group	Pathway	Genes (fold change)
Protein metabolism and modification (p = 1.45E − 08)	Protein modification	Prmt3 (1.57), P4ha1 (1.53), Ptpn11 (1.66), Mapk9 (1.57), 1500003O03Rik (1.53), Man2a1 (1.71), Siat9 (1.70), St3gal5 (1.61), St6gal1 (−2.02), Trib3 (−1.93), Ppm1k (−1.56), Sgk1 (−2.53), and Plxna2 (−1.64)
	Protein folding	Hsp105 (2.75), Hspb1 (1.64), Tcp1 (1.63), Dnajb1 (1.55), Ero1lb (1.71), Hspa8 (3.15), Hspb1 (2.11), Hsp90ab1 (2.02), LOC666904 (2.22), D3Ucla1 (1.79), Hspa2 (1.69), Hsp90ab1 (1.53), Fkbp5 (1.99), Irak2 (1.55), Camk2b (1.66), Bmx (1.50), Egfr (1.75), and Clpx (−1.59)
	Proteolysis	Usp2 (3.98), Serpina12 (3.64), Serpina5 (1.61), Serpina1e (1.57), Rhbdl1 (1.56), C1s (1.52), Ahsa1 (1.68), Ppid (1.63), Bag3 (1.62), Cul4a (1.53), Serpina7 (−1.66), Serpinf2 (−1.65), Usp18 (−1.62), Itih2 (−1.61), Ulk1 (−1.54), Casp6 (−1.60), and Mug2 (−1.56)
	Protein biosynthesis	Mrps21 (1.59), Eef2 (1.58), Eif4b (1.50), and Eif4ebp3 (2.76)
Carbohydrate metabolism (p = 0.0105)	Glycolysis	Gck (2.10), Pklr (1.69)
	Glycogen metabolism	Gys2 (1.92), Ppp1r3b (1.62), Pygl (1.54), and G6pc (−1.78)
	Other glycogen metabolisms	Man2a1 (1.71), Adh7 (1.67), and Tkt (2.14)
	Carbohydrate transport	Slc35b1 (1.57)
	Monosaccharide metabolism	Khk (1.68), Galt (−1.53), and Gnpda1 (−1.50)
	Other polysaccharide metabolisms	St3gal5 (1.61), Siat9 (1.70)
Immunity and defense (p = 1.83E − 07)	T-cell-mediated immunity	LOC56628 (2.05), H2-Q8 (1.72), H2-Q10 (1.52), Bmx (1.50), Raet1b (−1.63), Fkbp5 (1.99), Cxcl1 (1.60), and Gstt3 (−1.56)
	Macrophage-mediated immunity	Cish (1.92), Sdc4 (−1.65)
	Complement-mediated immunity	C6 (5.13), C9 (1.87), C8b (1.53), C1s (1.52), and Cfp (−1.51)
	Stress response	Hspa8 (3.15), Hspb1 (2.11), Hsp90ab1 (2.02), LOC666904 (2.02), D3Ucla1 (1.79), Hspa2 (1.69), Ahsa1 (1.68), and Hsp90ab1 (1.53)
	Detoxification	Gata1 (3.02), Gstp1 (2.75), Gsta3 (1.73), Gsta2 (1.59), and Gstm1 (1.55)