Table 2.
Proteomics applied in the effective mechanism of TCM treatment in vivo.
| Diseases | CHF, CHM, CHM compound, and acupuncture | Targets or signaling pathways | Proteomics methods | References |
|---|---|---|---|---|
| Cardiocerebrovascular diseases | ||||
| Arrhythmias | Dingxin recipe | Prohibitin | 2DE, MALDI-TOF MS | [50] |
| Ischemic myocardial injury | Buyang Huanwu decoction | Atrial natriuretic factor | 2DE, MALDI-TOF MS | [51] |
| Cardiovascular disorders | Salvianolic acid B | Integrin α2β | 2DE, MALDI-TOF MS/MS | [52] |
| Cardiovascular disorders | Salvianolic acids | Energy metabolism, lipid metabolism | 2DE, MALDI-TOF MS/MS | [53] |
| Epileptic seizures | Uncaria rhynchophylla | MIF and cyclophilin A | 2DE | [54] |
| Alzheimer's disease | Yizhijiannao granule | NADH dehydrogenase iron-sulfur protein 6 |
2DE, peptide mass fingerprint | [55] |
| Neurodegenerative diseases | Ginkgo biloba L. extracts | PPAP subunit Band CRMP2 | 2DE, MALDI-TOF MS | [56] |
| Cerebrovascular diseases | Tianma | Gnao1, Dctn2, Anxa5, Pacsin1, and Arf3 | iTRAQ | [43] |
| Hepatorenal diseases | ||||
| Liver cirrhosis | Yiguanjian decoction | Cu/Zn SOD, DJ-1 | 2DE, MALDI-TOF-TOF MS | [57] |
| Liver fibrosis | Fuzheng Huayu | Vimentin | 2DE/MS | [58] |
| Liver injury | Yin-Chen-Hao-Tang | Zinc finger protein 407, haptoglobin | RP-HPLC | [59] |
| Immunological liver injury | Salvia miltiorrhiza | PRDX6 | 2D-DIGE, MALDI-TOF MS | [60] |
| Nephropathy | Tanshinone IIA | Oxidative stress | 2DE | [61] |
| Diabetes | ||||
| Diabetes | Granules | Apolipoprotein E (apoE) and C3 | 2DE, MALDI-TOF MS/MS | [62] |
| Type 2 diabetes mellitus | ZiBuPiYin recipe | DRP-2 and PDHE1α | Fluorescence-based DIGE, MS | [63] |
| Type 2 diabetes mellitus | Tianqijiangtang capsule | Haptoglobin, transthyretin, and prothrombin | 2DE, MALDI-TOF-TOF/MS | [64] |
| Other diseases | ||||
| Gan stagnancy syndrome | — | TTR, aryl sulfotransferase | 2DE, MALDI-TOF MS | [65] |
| Functional dyspepsia | Wei Kangning | Glutathione S-transferase, pi2 | 2DE, MALDI-TOF MS | [66] |
| Spontaneously hypertensive | Formula | HSP-27, annexin-A1, MFN-2, and Rho | 2DE, MALDI-TOF MS | [67] |
| Allergic airway | Xiao-Qing-Long-Tang | Spectrin α2 | 2DE, MS, MS/MS | [68] |
| Silicosis | Gymnadenia conopsea | Cathepsin D precursor, peroxiredoxin-1 | 2DE, MALDI-TOF MS | [69] |
| Anxiety disorders | Polysaccharides | Beta-synuclein, DJ-1, and peroxiredoxin-2 | 2DE/MS | [70] |
| Normal | Acupuncture | NAD-isocitrate dehydrogenase | 2DE, MALDI-TOF MS | [71] |
| Normal | Acupuncture | Local stimulus response, energy metabolism | 2DE/MS | [72] |
| Asthma | Acupuncture | S100A8, RAGE, S100A11, and CC10 | 2DE, LC-MS/MS | [73] |