Table 2.

Different dietary nutraceuticals using for anticolon cancer and preventive medicine

Secondary metabolites	Sources	Cancer cell lines	Applications	Ref.
Oleuropein	Olive tree leaves	Colon cancer cell line	Protect DNA damage	75
Vitamin D (25-hydroxy vitamin D)	Milk and milk based products	Colon cancer cell line	Reducing the colon cancer development	76
Procyanidins	Apple fruit	SW 480, SW 620	Differentiation of apoptosis function	77
Scallian	Allium fistulosum	CT-26	Effect of inhibit colorectal tumor growth	78
Centella asiatica crude extract	Whole plant	Caco-2 colon cancer	Regulate the cell cycle	79
Salograriolide A	Centaurea ainetensis	HCT-116	Reduce the colon tumor formation	80
Avenanthramides	Oats	HCT-116	Attenuates of colon cancer cells	81
Brachylaena ramiflora crude extract	Whole plant	HCT-116	Control the p53 tumor gene	82
Crude Lentinus edodes extract	Mushroom fruit bodies	HCT-116	Regulate the apoptosis of cancer cells	83
Resveratrol	Grapes, wines	HCT-116	Stimulate p53 gene for apoptosis	84
Conjugated linolinic acid	Probiotic bacteria	Colorectal cancer	Enhance apoptosis of tumor cells	17
Crude phenolics extract	Cichorium endlvia. L.	HCT-116	Induction of IL-3 expression	35
Garlic crude extract	Allium sativum	HT-29	Inducing apoptotic cell death	66