. 2014 Nov 21;4(6):454–463. doi: 10.1016/j.apsb.2014.10.005

Table 4.

Characteristics of HP-SLNs after a 6-month stability studies at different conditions.

Temp (°C)/RH(%)	Time (month)	Characteristics parameter
		Particle size (nm)^a	PDI	Zeta potential (mV)^a	Entrapment efficiency (%)^a	Drug loading (%)^a
4±2	0	112.34±4.73	0.424	−18.6±1.7	72.53±2.64	26.61±0.85
	1	117.65±2.54	0.506	−17.6±1.5	71.54±1.20	26.35±0.42
	3	115.94±5.82	0.332	−17.3±1.2	71.23±1.94	26.27±0.63
	6	125.67±2.34	0.463	−16.1±2.6	71.92±2.45	26.45±0.86

25±2/60±5	0	112.34±4.73	0.424	−18.6±1.7	72.53±1.64	26.61±0.57
	1	112.21±1.04	0.556	−17.3±1.2	70.65±1.24	26.10±0.53
	3	119.76±5.57	0.575	−16.6±1.3	69.78±1.98	25.87±0.59
	6	135.34±5.86	0.637	−15.1±2.6	71.87±2.34	26.44±0.71

40±2/75±5	0	112.34±4.73	0.424	−18.6±1.7	72.53±2.64	26.61±0.75
	1	120.45±2.81	0.554	−14.2±1.9	70.39±2.85	26.04±0.91
	3	355.35±3.98	0.594	−11.6±2.3	69.53±1.27	25.80±0.65
	6	1345.93±4.60	0.642	−8.34±3.9	70.36±2.54	26.03±0.89

PS, Particle size; PDI, polydispersity index.

Data are expressed as mean±SD, n=3; P<0.05 (The measurements obtained at each time point (1, 3 and 6 months) at specific storage condition were compared with measurements obtained at zero month at that storage condition. Comparison of different parameters was also made between different temperatures.)