Table 5.
Pharmacokinetic parameters of HP after HP-SLNs i.n., HP sol. i.n. and HP sol. i.v. administration to rats in brain and plasma.
| Parameter (unit) | SLNs i.n. |
Drug solution i.n. |
Drug solution i.v. |
|||
|---|---|---|---|---|---|---|
| Brain | Plasma | Brain | Plasma | Brain | Plasma | |
| Cmax (ng/mL) | 329.17±20.89 | 393.5±24.63 | 90.13±6.28 | 306.96±13.47 | 76.95±7.62 | 2190±60.67 |
| Tmax (h) | 2 | 4 | 2 | 1 | 1 | 0.167 |
| AUC0–24 h (ng·h/mL) | 2172.33±60.41 | 2433.05±18.54 | 623.16±8.51 | 1460.71±15.67 | 433.65±15.46 | 11,464.59±150.45 |
| AUC0–∞ (ng·h/mL) | 2389.17±78.82 | 2612.31±40.67 | 683.15±30.17 | 1681.82±32.83 | 500.82±12.78 | 12,017.5±180.87 |
| AUMC0–24 h (ng·h2/mL) | 12,172.67±56.59 | 13,725.21±135.43 | 2881.23±27.08 | 8696.86±124.78 | 2881.31±30.76 | 57,642.09±580.45 |
| AUMC0–∞ (ng·h2/mL) | 15,665.20±25.59 | 19,864.67±256.43 | 7079.16±35.53 | 14,650.31±145.75 | 5199.46±120.67 | 70,374.14±960.87 |
| Ke (h−1) | 0.079±0.0065 | 0.097±0.003 | 0.077±0.005 | 0.11±0.003 | 0.095±0.003 | 0.15±0.007 |
| MRT (h) | 12.60±0.99 | 7.60±0.32 | 9.17±0.45 | 8.9±0.57 | 10.38±0.65 | 5.92±0.57 |
All data are expressed as mean±SD, n=6; P<0.05 (Pharmacokinetics parameters after various route of administration were compared with each other).