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. 2015 Nov 2;5:15970. doi: 10.1038/srep15970

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PPARγ, which maybe induced by cholesterol or unknown lipid, activated the transcription of LPL to further catalyze and transport circulation lipids (LDL-c or others) into the liver. Concurrently, De Novo synthesis, oxidation, and export of lipids were down-regulated, eventually leading to lipid accumulation, inflammation and fibrosis in the liver of tree shrew.