Figure 3.

(a) In vitro staining of Aβ plaques with AOI-987 in a transgenic mouse brain section [scale bars, 1 mm (large panel) and 100 μm (lower panels)]. (b) In vivo images of female 17-month-old APP23 transgenic (top row) and wild-type (middle row) mice at different time points (30, 60, 120, 240 min) after injected i.v. with 0.1 mg/kg AOI-987, and corresponding images of a female 17-month-old transgenic APP23 mouse treated with 0.9% saline (bottom row) (scale bar, 1 cm; color scale bars in arbitrary units). (c) Ex vivo NIRF image of a brain section (20 μm thickness) of 16-month-old female transgenic mouse administrated with 0.1 mg/kg AOI-987 (scale bar, 100 μmol/L). (Adapted with permission from Ref.⁴⁹. Copyright 2005 Macmillan Publishers Ltd.: Nature Biotechnology.)