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. Author manuscript; available in PMC: 2015 Nov 2.
Published in final edited form as: Epidemiol Infect. 2012 Jan 11;140(11):2003–2013. doi: 10.1017/S0950268811002858

Table 2.

Estimates of the annual prevalence and total cost (in US$) of hospitalizations for selected waterborne diseases in the USA

Medicaid Medicare Commercial Uninsured Total
PRIMARILY WATERBORNE
Giardiasis
 Mean total cost/hospitalization $3863 $11 842 $10 588 a $9607
 Proportion of hospitalizations with
  type of insurance
20% 29% 39% 9%
 Number of hospitalizations/year 716 1038 1397 306 3581
 Total hospitalization cost $2 766 681 $12 297 799 $14 787 095 a $34 401 449b
Cryptosporidiosis
 Mean total cost/hospitalization $16 203 $9361 $20 073 $16 797
 Proportion of hospitalizations
  with type of insurance
21% 23% 47% 9%
 Number of hospitalizations/year 572 627 1281 233 2725
 Total hospitalization cost $9 272 167 $5 867 007 $25 708 495 a $45 770 572b
Legionnaires’ disease
 Mean total cost/hospitalization c $26 741 $38 363 a $33 366
 Proportion of hospitalizations with
  type of insurance
8% 43% 39% 6%
 Number of hospitalizations/year 1040 5590 5070 795 13 000
 Total hospitalization cost c $149 482 190 $194 500 410 a $433 752 020b
Otitis externa
 Mean total cost/hospitalization $4741 $7903 $5910 a $6293
 Proportion of hospitalizations with
  type of insurance
15% 28% 45% 7%
 Number of hospitalizations/year 664 1239 1992 316 4426
 Total hospitalization cost $3 147 550 $9 794 030 $11 770 947 a $27 851 446
NTM infection
 Mean total cost/hospitalization $21 041 $20 787 $38 432 a $25 985
 Proportion of hospitalizations with
  type of insurance
22% 48% 21% 5%
 Number of hospitalizations/year 3679 7933 3416 750 16 386
 Total hospitalization cost $77 402 622 $164 909 131 $131 270 710 a $425 788 469b
Pulmonary NTM infection d
 Mean total cost/hospitalization $12 725 $23 402 $37 579 a $25 409
 Proportion of hospitalizations 16% 57% 20% 4%
 Number of hospitalizations/year 1248 4386 1510 290 7659
 Total hospitalization cost $15 885 069 $102 632 748 $56 753 918 a $194 597 422b
Disseminated NTM infection d
 Mean total cost/hospitalization $21 080 $12 310 $47 123 a $23 388
 Proportion of hospitalizations with
  type of insurance
31% 40% 19% 6%
 Number of hospitalizations/year 2008 2573 1221 360 6447
 Total hospitalization cost $42 337 221 $31 675 113 $57 535 633 a $161 895 431b
Primarily waterborne total hospitalizations/year 6671 16 428 13 155 2400 40 118
Primarily waterborne total cost d $92 589 019e $342 350 156 $378 037 657 a $967 563 956b
PARTIALLY WATERBORNE
Campylobacteriosis
 Mean total cost/hospitalization $4328 $7961 $10 806 a $8915
 Proportion of hospitalizations with
  type of insurance
16% 30% 45% 6%
 Number of hospitalizations/year 2118 3972 5958 753 13 240
 Total hospitalization cost $9 168 435 $31 621 092 $64 382 148 a $118 048 105b
Salmonellosis
 Mean total cost/hospitalization $4036 $8605 $8687 a $7687
 Proportion of hospitalizations with
  type of insurance
21% 28% 41% 6%
 Number of hospitalizations/year 4857 6476 9482 1426 23 128
 Total hospitalization cost $19 602 368 $55 724 603 $82 374 304 a $177 792 568b
Shigellosis
 Mean total cost/hospitalization $3510 $17 841 $9675 a $8721
 Proportion of hospitalizations with
  type of insurance
38% 17% 32% 10%
 Number of hospitalizations/year 2087 933 1757 542 5491
 Total hospitalization cost $7 323 896 $16 654 038 $17 000 136 a $47 884 375b
Haemolytic uraemic syndrome
 Mean total cost/hospitalization $29 968 $42 803 $63 605 a $51 261
 Proportion of hospitalizations with
  type of insurance
20% 27% 46% 4%
 Number of hospitalizations/year 475 641 1092 99 2373
 Total hospitalization cost $14 222 813 $27 424 310 $69 429 946 a $121 642 495b
Toxoplasmosis
 Mean total cost/hospitalization $39 294 $35 982 $54 783 a $44 705
 Proportion of hospitalizations with
  type of insurance
42% 19% 17% 14%
 Number of hospitalizations/year 3733 1689 1511 1286 8889
 Total hospitalization cost $146 699 434 $60 770 360 $82 784 235 a $397 386 567b
Partially waterborne total hospitalizations/year 13 270 13 711 19 800 4106 53 121
Partially waterborne total cost $197 016 945 $192 194 403 $315 970 768 a $862 754 111b

NTM, Non-tuberculous mycobacteria.

Data sources : 2006–2007 Nationwide Inpatient Sample; Marketscan 2004–2005 Multistate Medicaid and 2006–2007 Medicare Supplemental and Commercial Claims databases. All costs in 2007 US dollars.

a

Costs for uninsured patients could not be estimated from the insurance claims-based Marketscan databases.

b

Totals are higher than the sum of Medicaid, Medicare, and Commercial columns because the total includes the uninsured and other insurance sources (e.g. Tricare).

c

The number of cases of Legionnaires’ disease in the Marketscan Medicaid database was too small (<5 cases) to calculate cost estimates.

d

Pulmonary and disseminated NTM infections were a subset of all NTM infections and are not included in total cost calculations.

e

Not including Legionnaires’ disease costs.