Table 4.
Susceptibilities and clinical details of rare Candida isolates Caspofungin represents echinocandin susceptibilities (caspofungin, anidulafungin, micafungin). The breakpoints for echinocandins and/or fluconazole were not established. CVC, Central venous catheter; HCC, hepatocellular carcinoma; PICC, peripherally inserted central catheter; TACE, transcatheter chemo-embolization; TPN, total parenteral nutrition.
| Species | Frequency (n) | Source | Patient characteristics | MIC range (µg ml−1) |
||||
|---|---|---|---|---|---|---|---|---|
| Caspofungin | Fluconazole | Voriconazole | Itraconazole | Amphotericin | ||||
| C. viswanathii | 3 | Blood culture | 28-Year-old male with renal transplant |
0.03–0.12 | 0.5–4.0 | 0.015–0.25 | 0.03–0.5 | 0.032–0.094 |
| 70-Year-old diabetic female | ||||||||
| C. pelliculosa | 3 | Two blood cultures, one CVC tip |
28-Day-old male (history not available) |
0.015–0.03 | 0.25–8.0 | <0.008–0.25 | 0.06–0.5 | 0.016–0.5 |
| 13-Year-old female with malignancy and CLABSI |
||||||||
| 43-Year-old male with CLABSI and complicated abdominal infection |
||||||||
| C. utilis | 2 | Blood cultures | Two neonates with late- onset neonatal sepsis |
0.015–0.5 | 1.0 | 0.03–0.06 | 0.25 | 0.032–0.047 |
| Novel Candida species | 2 | Blood cultures | 18-Month-old female with burn wound infection on TPN; 28-year-old male on chemotherapy; both received multiple antibiotics |
0.06–0.25 | 0.5–4.0 | 0.015 | 0.5 | 0.047–0.38 |
| C. fabianii | 1 | Blood culture | Neonate; clinical information not available |
0.03 | 0.5 | 0.03 | 0.5 | 0.094 |
| C. kefyr | 1 | Blood culture | 65-Year-old male; HCC, post-TACE with abdominal abscess and PICC line for chemotherapy |
0.12 | 0.5 | 0.03 | 0.5 | 0.38 |
| C. rugosa | 1 | Blood culture | 70-Year-old female with knee replacement, bed sores and Alzheimer’s disease |
1.0 | 1.0 | 0.008 | 0.5 | 0.75 |