Figure 3.

Targeting TLR2 reduces AAA lesions in vascular tissue of CaCl₂-induced AAA. (A and B) Blocking TLR2 attenuated the expression (A) and activities of MMP-2/9 (B) in the CaCl₂-injured vascular tissue (n=6). (C and D) CaCl₂ stimulated a time-dependent increase in α-SMA expression in vascular tissue (n=5/time point/group) and targeting TLR2 decreased the expression of α-SMA (n=6). (E) Targeting TLR2 reduced the content of collagen I/III in aneurismal tissue stained by picrosirius red (n=8). Data are means±SD. ^#P<0.05, ^##P<0.01, ^###P<0.001, compared to sham group. ^⁎P<0.05, ^⁎⁎P<0.01, ^⁎⁎⁎P<0.001, compared to CaCl₂ group.