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. Author manuscript; available in PMC: 2015 Nov 2.
Published in final edited form as: Pigment Cell Melanoma Res. 2012 Nov 16;26(1):78–87. doi: 10.1111/pcmr.12030

Figure 4.

Figure 4

Embryonic melanoblasts in cephalic and otic vesicle regions of Dct‐lacZ transgenic +/+ and MitfMi-wh/+ embryos. (A) At E12.5, numerous Dct-lacZ+ melanoblasts are present in the periorbital region, throughout the cephalic region, and in the region of the otic vesicle (ov) in this wild-type transgenic embryo. (B) Fewer melanoblasts in the cephalic and otic vesicle (ov) region of E12.5 MitfMi‐wh/+ transgenic embryonic littermate. (C) Quantification of Dct-lacZ melanoblast numbers in cephalic region of MitfMi-wh/+ and +/+ embryonic littermates at E10.5 and E12.5. Melanoblasts were counted as described in Methods. P < 0.10 by Student’s two-tailed t test for difference between MitfMi-wh/+ and +/+ embryos at E12.5.