Table S3.

Potential donor peptides derived from pancreatic proteins for N-terminal WE14 modification to create strong agonists

Protein source*	aa nos.†	IAg7 groove position (p) 1‡ 2 3 4
Chromogranin A	48–51	I L S I
	147–150	E A T T
	197–200	Q A T G
	203–206	E R G L
	205–208	G L S A
	349–352	E L T A
	424–427	S L S A
Insulin-1/2	43–46	E L G G
	53–56	T L A L
Secretogranin-1	85–88	G A P V
	183–186	E A S A
	273–276	G R S G
	303–306	V A T V
	495–498	R L G A
	627–630	V L T A
Secretogranin-2	26–29	I R A L
	166–169	S L A T
	179–182	K L T G
	255–258	K R S G
	259–262	Q L G L
	358–361	E L A V
	389–392	K A P G
	402–405	G L S V
	538–541	R I P V

^*Islet-specific proteins highly enriched in a partially purified antigen preparation (7).

^†After cleavage of the signal peptide.

^‡May not be required.