Fig. 3.

(A) The structure of racemic M2-TM/OG contains three distinct heterochiral interfaces. (B) Distances calculated between side-chain centers-of-mass indicate that the largest interface in the structure of racemic M2-TM/OG contains KIH interactions reflecting a heptad sequence repeat. The remaining two interfaces (C and D) contain spacings between side-chain knobs that are consistent with a nonheptad sequence repeat. (Bottom) Sequence positions of knobs from each heterochiral interface (color-coded) are shown as asterisks below the M2-TM sequence, with marginal interactions (containing a distance ≥7.4 Å) enclosed in parentheses. Distances are reported in units of angstroms (Å). In B–D, side-chain knobs of l-M2-TM are shown in blue.