Fig. S1.

Model fits of cfdDNA early dynamics. (A) Comparison of double- (blue line) and single-exponential (black line) fit of cfdDNA levels recorded for lung transplant recipients as a function of time posttransplant (blue dots). The double-exponential fit is better at capturing the time dynamics at later time points. (B) Weighted residuals (weighted by the square of the cfdDNA levels) for the single- (black line) and double-exponential model (blue line) as function of time posttransplant. The R-squared measure of the goodness of the fit with weighted residuals is 0.89 for the double-exponential model and 0.47 for the single-exponential model.