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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Bioessays. 2015 Sep 10;37(11):1243–1252. doi: 10.1002/bies.201500081

Figure 3.

Figure 3

Simulations of single-photon responses for a mouse rod with modified PDE kinetics or expression. Currents have been normalized to the circulating current in darkness. A: Simulations assuming a rate of spontaneous cGMP hydrolysis set equal to the diffusion-limited rate for light activated PDE. This high spontaneous PDE rate would give a βdark of approximately 55 s−1. B: Simulations of single-photon responses again assuming a rate of spontaneous cGMP hydrolysis set equal to the diffusion-limited rate for light activated PDE as in A but with a PDE density that is 13-fold lower than normal to reduce the amount of spontaneous PDE activations so that βdark is maintained at 4.1 s−1. C: Single-photon simulations with the PDE density reduced by a factor of 5 so as to be the same as in toad. All of A–C reprinted from Reingruber et al. [10] with permission of the authors, copyright 2013 National Academy of Sciences, U.S.A.