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. 2015 Apr 10;123(11):1138–1144. doi: 10.1289/ehp.1408663

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Effects of arsenic on PEPCK mRNA expression and glycogen content in liver and on insulin secretion in islets of female mice with or without ovariectomy. Mice were treated with D.D. water or with As₂O₃ (0.05 or 0.5 ppm) in drinking water in the presence or absence of 17β-estradiol (E₂; 10 μg/kg) for 6 weeks. The liver was isolated to analyze PEPCK mRNA expression (A) and glycogen content (B). The pancreatic islets were isolated to analyze glucose-stimulated insulin secretion (C). Data are mean ± SEM (n = 6/group). *p < 0.05 vs. sham D.D. water. ^#p < 0.05 vs. OVX D.D. water. ^$p < 0.05 vs. OVX with As₂O₃.