Table 1.

Effects of arsenic (0.05 or 0.5 ppm) on uterine and body weights at 6 weeks in female mice with or without ovariectomy.

Treatment	Uterine weight		Body weight/gain (g)
	mg	Fold increase
Abbreviations: As, As2O3; E2, 17β-estradiol; OVX, ovariectomy. Values are means ± SEM (n = 12). *p < 0.05 vs. sham. #p < 0.05 vs. OVX.
Sham	181.1 ± 15.8	—	32.4 ± 0.3/1.61 ± 0.28
As 0.05	215.2 ± 17.0	1.19	33.3 ± 0.4/1.58 ± 0.43
As 0.5	182.6 ± 16.4	1.01	33.0 ± 1.3/1.38 ± 0.21
Sham + E2	217.0 ± 9.2	1.20	35.3 ± 0.8/2.02 ± 0.23
As 0.05 + E2	213.0 ± 11.5	1.18	35.4 ± 0.6/2.18 ± 0.24
As 0.5 + E2	204.7 ± 14.3	1.13	35.3 ± 0.7/1.95 ± 0.56
OVX	20.9 ± 3.0*	0.12	39.6 ± 1.0/6.45 ± 1.10*
OVX + As 0.05	19.7 ± 1.9*	0.11	37.2 ± 0.8/6.24 ± 1.40*
OVX + As 0.5	19.8 ± 2.3*	0.11	38.5 ± 1.3/6.65 ± 1.43*
OVX + E2	105.6 ± 3.2*,#	0.58	33.8 ± 0.5/1.88 ± 0.47#
OVX + As 0.05 + E2	104.4 ± 5.0*,#	0.58	33.8 ± 0.6/1.83 ± 0.46#
OVX + As 0.5 + E2	96.6 ± 4.3*,#	0.53	32.1 ± 0.7/1.81 ± 0.37#