Table 2.
Effects of arsenic (0.05 or 0.5 ppm) on HOMA-IR in female mice with or without ovariectomy in the presence or absence of 17β-estradiol (E2).
| Treatment | 2 week | 4 week | 6 week |
|---|---|---|---|
| Abbreviations: As, As2O3; E2, 17β-estradiol; OVX, ovariectomy. Values are mean ± SEM (n = 12/group). *p < 0.05 vs. sham control. #p < 0.05 vs. OVX control. | |||
| Sham control | 1.91 ± 0.24 | 1.77 ± 0.10 | 1.64 ± 0.16 |
| Sham + As 0.05 | 2.03 ± 0.11 | 1.85 ± 0.15 | 1.66 ± 0.13 |
| Sham + As 0.5 | 1.87 ± 0.11 | 1.94 ± 0.31 | 1.65 ± 0.12 |
| Sham + E2 | 2.15 ± 0.29 | 2.54 ± 0.27 | 1.70 ± 0.20 |
| Sham + As 0.05 + E2 | 2.14 ± 0.09 | 1.77 ± 0.21 | 1.74 ± 0.13 |
| Sham + As 0.5 + E2 | 2.33 ± 0.22 | 1.70 ± 0.20 | 1.78 ± 0.15 |
| OVX control | 2.89 ± 0.29 | 2.56 ± 0.32 | 2.44 ± 0.26 |
| OVX + As 0.05 | 4.40 ± 0.86* | 6.68 ± 1.00* | 4.31 ± 0.28* |
| OVX + As 0.5 | 5.65 ± 1.11* | 3.54 ± 0.29* | 3.20 ± 0.34* |
| OVX + E2 | 2.35 ± 0.24 | 2.34 ± 0.40 | 1.71 ± 0.14 |
| OVX + As 0.05 + E2 | 2.41 ± 0.25# | 2.97 ± 0.37# | 2.23 ± 0.16# |
| OVX + As 0.5 + E2 | 2.61 ± 0.20# | 2.47 ± 0.35# | 2.10 ± 0.20# |