. 2014 Sep 1;1(Suppl 1):10.3402/ecrj.v1.25535. doi: 10.3402/ecrj.v1.25535

Table 2.

Genetic and environmental correlations between asthma symptoms and intermediate asthma phenotypes in a sample of 575 Danish adult twins

	Over	Whee	Short	Chest	Cough	Rhin	FEV₁	FVC	FE/FV	DRS	FeNO	IgE	SPT	HDM
Overall symptom severity		0.50^***	0.47^***	0.26^***	0.86^***	0.20^*	−0.22^*	−0.20^*	−0.18^*	0.32^***	0.09	0.08	0.22^*	0.15
Wheezing	0.68^**		0.64^***	0.17	0.24^**	0.17^*	−0.10	−0.09	−0.07	0.34^***	0.16^*	0.11	0.18^*	0.19^*
Shortness of breath	0.72^**	1.00^***		0.17^**	0.20^*	0.14	−0.26^***	−0.13	−0.19^*	0.44^**	0.12	−0.05	0.15^*	0.11
Chest tightness	0.61	−0.15^**	0.27		0.27^***	−0.06	−0.02	−0.04	−0.03	0.11^*	−0.03	0.00	0.01	−0.01
Cough	1.00^***	0.52	0.58^*	0.68^*		0.12	−0.10	−0.01	−0.23^**	0.21^*	0.12	0.05	0.22^**	0.05
Rhinitis severity	0.02	0.63^*	0.37	−0.43	0.00		0.03	−0.04	0.06	0.27^**	0.22^*	0.12	0.31^***	0.12
FEV₁	−0.27	−0.40	−0.45^**	0.07	−0.04	0.02		0.75^***	0.53^***	0.35^**	−0.02	−0.02	0.00	0.01
FVC	−0.01	−0.27	−0.44^**	−0.59	−0.07	−0.01	0.90^***		0.13	−0.01	0.04	−0.06	−0.02	−0.02
FEV₁/FVC	0.09	0.02	0.14	−0.37	0.22	0.16	−0.30^**	0.67^***		0.46^***	−0.11	0.07	0.01	0.05
DRS_methacholine	0.25	0.62^**	0.43^*	−0.34	0.22	0.09	0.39^**	−0.37^**	0.26^*		0.34^**	0.24^*	0.27^*	0.12
FeNO	0.15	0.13	0.09	−0.50	−0.03	0.31	0.29^*	0.19	−0.02	0.20		0.08	0.29^**	0.26^**
Serum total IgE	−0.03	0.32	0.11	0.90	−0.03	0.40^*	0.13	−0.03	0.00	0.24^*	0.37^***		0.35^***	0.28^**
Positive SPT	−0.12	0.24	0.10	−0.07	−0.23	0.90^***	0.21	0.08	0.14	0.26^*	0.41^***	0.34^**		0.46^***
HDM sensitization	−0.17	0.21	0.11	−0.63	−0.22	0.54^***	0.18	0.04	0.17	0.31^*	0.44^***	0.25^*	0.73^***

Genetic correlations are below the diagonal; environmental correlations are above the diagonal.

p<0.05

^**

p<0.01

^***

p<0.001 (highlighted in bold print). Modified from [III].