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Model of haem/haemoglobin iron utilization by C. albicans. Erythrocytes are bound and lysed by C. albicans hyphae by as-yet unknown molecular mechanisms (inset). Released haem/haemoglobin is bound at the outer surface of the cell wall by members of the Rbt5 family and in the surrounding environment by the secreted Csa2. Haem is shuttled through the cell wall via an Rbt5-Pga7 relay network and endocytosed, before being metabolized in the vacuole by the haem oxygenase, Hmx1.
