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Model of the antifungal activity of neutrophil extracellular traps and calprotectin. Neutrophils sense the larger physical dimensions of pathogens such as C. albicans hyphae and undergo NETosis. The high levels of calprotectin decorating the NETs elicit local zinc depletion against the fungus (inset, top left). Viable neutrophils target the fungus with ROS; C. albicans counterattacks with expression of the copper-only superoxide dismutase, Sod5 (inset, bottom right).
