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Model of zinc homeostasis in the model yeast, S. cerevisiae. The zinc-responsive transcription factor Zap1 responds to diminishing metal levels by triggering expression of the zinc importers, Zrt1 and Zrt2, and the vacuolar zinc exporter, Zrt3. In the presence of elevated zinc, the metal is efficiently detoxified in the fungal vacuole via Zrc1 and Cot1.
