TABLE 5.
Mean ADC MR1 (×10−6 mm2/s) paired t-test by site |
Estimated Dmean with GNC |
Lower 95% CI | Upper 95% CI | P-value |
---|---|---|---|---|
Site 1A | −135.6 | −155.6 | −115.5 | 4.7*10−14 |
Site 3 | −2.3 | −3.6 | −0.9 | 0.0096 |
Site 4 | −130.5 | −179.6 | −81.4 | 0.0001 |
Site 5 | −91.4 | −126.1 | −56.6 | 0.0003 |
% change ADC with GNC inter-site comparison 2 sample t-test |
Difference in estimated means (%) |
Lower 95% CI | Upper 95% CI | P-value |
Site 1A to Site 3 | 11.08 | −12.46 | −9.71 | 5.1*10−16 |
Site 1A to Site 4 | −0.14 | −3.84 | 4.12 | 0.9407 |
Site 1A to Site 5 | −4.04 | 1.24 | 6.84 | 0.0079 |
Site 3 to Site 4 | 10.94 | −14.78 | −7.11 | 8.2*10−5 |
Site 3 to Site 5 | 7.04 | −9.63 | −4.45 | 0.0002 |
Site 4 to Site 5 | −3.90 | −0.44 | 8.25 | 0.0751 |
ΔADCET (% change) paired t-test by site |
Estimated Δmean with GNC |
Lower 95% CI | Upper 95% CI | P-value |
All patients | −0.01 | −0.58 | 0.56 | 0.94 |
Site 1A | 0.14 | −0.78 | 1.07 | 0.75 |
Site 3 | −0.04 | −0.16 | 0.07 | 0.35 |
Site 4 | −0.86 | −2.03 | 0.30 | 0.13 |
Site 5 | 0.54 | −0.77 | 1.85 | 0.37 |