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Clinical and laboratory indications for considering hydroxyurea therapy in children with sickle cell anemia.
| Clinical |
| Painful episodes |
| Dactylitis |
| Acute Chest Syndrome |
| Laboratory |
| Severe anemia |
| Low HbF |
| High White Blood Cell count |
| Elevated LDH |
| Organ dysfunction |
| Hypoxemia |
| Proteinuria |
| Elevated transcranial Doppler (TCD) velocities |
| Cerebrovascular disease |
| Miscellaneous |
| Poor growth and development |
| Sibling on therapy |
| Parental request |
