Table 3. Characteristics of patients with confirmed CAD.
Demographic and clinical data of all patients with confirmed CAD and divided by CXCL4 quartiles. For each parameter the coefficient and P value with CXCL4 plasma levels is indicated as calculated by Pearson’s correlation. Continuous variables are indicated as mean ± standard deviation, categorical variables are indicated as absolute number (percentage).
| Parameter | All patients (n = 217) | 1st quartile (n = 50) | 2nd quartile (n = 57) | 3rd quartile (n = 55) | 4th quartile (n = 57) | Correlation coefficient with CXCL4 levels | P value |
|---|---|---|---|---|---|---|---|
| Demographics | |||||||
| Age (years) | 65.5 ± 9.6 | 69.6 ± 8.4 | 63.9 ± 9.7 | 64.8 ± 9.8 | 64.7 ± 9.6 | -0.129 | 0.186 |
| Male sex | 70 (63.6) | 16 (72.2) | 20 (60.6) | 15 (55.6) | 19 (67.9) | 0.040 | 0.677 |
| Coronary risk factors | |||||||
| 1. Arterial hypertension | 91 (82.7) | 29 (90.9) | 28 (84.8) | 22 (81.5) | 21 (25.0) | -0.057 | 0.551 |
| 2. Hypercholesterolemia | 78 (70.9) | 18 (81.8) | 24 (72.7) | 20 (74.5) | 16 (57.1) | -0.124 | 0.196 |
| 3. Diabetes mellitus | 9 (8.2) | 2 (9.1) | 3 (9.1) | 1 (3.7) | 3 (10.7) | -0.038 | 0.697 |
| 4. Family history of coronary artery disease | 54 (49.1) | 13 (59.1) | 15 (45.5) | 14 (51.9) | 12 (42.9) | -0.130 | 0.185 |
| 5. Smoking | 37 (33.6) | 7 (31.8) | 15 (45.5) | 7 (25.9) | 8 (28.6) | -0.116 | 0.228 |
| 6. Obesity | 17 (15.5) | 6 (27.3) | 6 (18.2) | 2 (7.4) | 3 (10.7) | -0.093 | 0.342 |
| Total number of risk factors (0–5) | 2.8 ± 1.2 | 3.2 ± 1.3 | 3.0 ± 1.1 | 2.6 ±1.0 | 2.4 ± 1.3 | -0.236 | 0.031* |
| Cardiac medications | |||||||
| Aspirin (100 mg/day) or clopidogrel (75 mg/day) | 61 (55.5) | 13 (40.9) | 21 (63.6) | 14 (51.9) | 13 (46.4) | -0.024 | 0.808 |
| Coumadin | 7 (6.4) | 4 (18.2) | 0 (0.0) | 0 (0.0) | 3 (10.7) | 0.005 | 0.957 |
| β-blocker | 61 (55.5) | 18 (81.8) | 18 (54.5) | 12 (44.4) | 13 (46.4) | -0.103 | 0.302 |
| ACE inhibitor or angiotensin receptor blocker | 53 (48.2) | 14 (63.6) | 15 (45.5) | 14 (51.9) | 10 (35.7) | -0.093 | 0.356 |
| Statin | 57 (51.8) | 14 (63.6) | 21 (63.6) | 11 (40.7) | 11 (39.3) | -0.070 | 0.487 |
| Nitrates | 4 (3.6) | 1 (4.5) | 1 (3.0) | 0 (0) | 2 (7.1) | 0.206 | 0.072 |
| Laboratory data | |||||||
| CXCL4 (μg/mL) | 12.5 ± 4.5 | 6.6 ± 3.2 | 10.8 ± 0.8 | 13.7 ± 0.9 | 17.9 ± 2.7 | - | - |
| High sensitivity CRP (mg/L) | 4 ± 7 | 2 ± 0 | 7 ± 11 | 2 ± 0 | 2 ± 1 | -0.85 | 0.816 |
| High sensitivity troponin T (pg/mL) | 7 ± 9 | 14 ± 16 | 4 ± 2 | 8 ± 9 | 4 ± 2 | -0.183 | 0.360 |
* P<0.05.