Table 1.
Statistical analysis of the rs7903146 genotypes and metabolic phenotypes among Iranians of different ethnicities
| Genotype | Metabolic phenotype | n | Ethnicities
|
Statistical analysis
|
|||||
|---|---|---|---|---|---|---|---|---|---|
| Fars | Kurd | Lure | Turk | χ2 | P-value | ||||
| C/C | EM | 87 | 38 (43.68%) | 9 (10.34%) | 8 (9.2%) | 32 (36.78%) | 86 | <0.01* | |
| 95% CI | 33.3–54.1 | 3.9–16.7 | 3.1–15.3 | 26.6–46.9 | |||||
| C/T | IM | 199 | 134 (67.34%) | 6 (3.02%) | 19 (9.55%) | 40 (20.1%) | 198 | <0.01* | |
| 95% CI | 60.8–73.9 | 0.6–5.4 | 5.5–13.6 | 14.5–25.7 | |||||
| T/T | PM | 14 | 6 (42.86%) | 3 (21.43%) | 2 (14.29%) | 3 (21.43%) | 13 | 0.005* | |
| 95% CI | 16.9–68.8 | 0.1–4.2 | 0.01–3.2 | 0.1–4.2 | |||||
| Geographic | |||||||||
| East | North | South | West | Central | |||||
| C/C | EM | 87 | 2 (2.3%) | 26 (29.89%) | 17 (19.54%) | 7 (8.05%) | 35 (17.4%) | 41.908 | <0.01* |
| 95% CI | 0.0–5.4 | 20.3–39.5 | 11.2–27.9 | 2.3–13.8 | 29.9–50.5 | ||||
| C/T | IM | 199 | 24 (12.06%) | 45 (22.61%) | 12 (6.03%) | 20 (10.05%) | 98 (39.8%) | 121.327 | <0.01* |
| 95% CI | 7.5–16.6 | 16.8–28.4 | 2.7–9.3 | 5.9–14.2 | 42.3–56.2 | ||||
| T/T | PM | 14 | 0 | 1 (7.14%) | 5 (35.71%) | 4 (28.57%) | 4 (28.57%) | 2.571 | <0.01* |
| 95% CI | – | 6.3–20.6 | 10.6–60.8 | 4.9–52.2 | 4.9–52.2 | ||||
Notes: Data presented as number (percentage).
*
Statistically significant (P<0.05); –not present.
Abbreviations: EM, extensive metabolizer; IM, intermediate metabolizer; PM, poor metabolizer; CI, confidence interval.