Table 5 Treatment for high-risk disease (reprinted from 41, Copyright 2014 with permission from Current Oncology Reproduction).

	Agent	Regimen
Day 1	etoposide	100 mg/m2 intravenously over 30 min
	actinomycin D	0.5 mg intravenous bolus
	methotrexate	300 mg/m2 intravenously over 12 h
Day 2	etoposide	100 mg/m2 intravenously over 30 min
	actinomycin D	0.5 mg intravenous bolus
	folinic acid	15 mg intravenously or orally, every 12 h for 4 doses, starting 24 h after the start MTX infusion
Day 8	vincristine	1 mg/m2 intravenous bolus
	cyclophosphamide	600 mg/m2 over 30 min