Day 1 |
dexamethasone |
20 mg orally 12 and 6 h before paclitaxel |
cimetidine |
30 mg in 100 ml NaCl intravenously over 30 min |
chlorphenamine |
10 mg intravenous bolus |
paclitaxel |
135 mg/m2 in 250 ml NaCl intravenously over 3 h |
mannitol |
10 % in 500 ml intravenously over 3 h |
cisplatin |
60 mg/m2 in 1 l NaCl intravenously over 3 h |
post-hydration |
1 l NaCl + 20 mmol KCL + 1 g MgSO4 intravenously oder 2 h |
Day 15 |
dexamethasone |
20 mg orally 12 and 6 h before paclitaxel |
cimetidine |
30 mg in 100 ml NaCl intravenously over 30 min |
chloramphenamine |
10 mg intravenous bolus |
paclitaxel |
135 mg/m2 in 250 ml NaCl intravenously over 3 h |
etoposide |
150 mg/m2 in 1 l NaCl intravenously over 1 h |