Mean change scores (each time point minus baseline from beginning of session) for the cocaine-craving Visual Analog Scale (VAS), the 14-item Cocaine Craving Questionnaire (CCQ-14), and mean arterial blood pressure (MABP). Solid symbols: propranolol group (n = 18). Open symbols: placebo group (n = 15). Propranolol/placebo was administered in the intervention session only (left-hand panels), 75 min before the neutral script. Error bars show standard error of the mean. Results show unexpectedly strong cocaine craving in the propranolol group in the intervention session (for which we had hypothesized no acute effect of propranolol on craving), which seemed to persist, though not to a statistically significant degree, in the re-exposure/test sessions (for which we had hypothesized a beneficial effect of prior propranolol exposure).