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. Author manuscript; available in PMC: 2016 Nov 2.
Published in final edited form as: Integr Biol (Camb). 2015 Nov 2;7(11):1454–1465. doi: 10.1039/c5ib00217f

Figure 5. Comparative effects of force inhibition and FN fibrillogenesis inhibition.

Figure 5

Effects of FN fibrillogenesis inhibition on force generation were compared to inhibition with the Rho Kinase inhibitor Y27632, which inhibits myosin activity and contractility. Inhibition with either FUD or Y27632 showed similar effects on total force per cell. The effects of Y27632 were more pronounced on soft (4.3 kPa) micropillars relative to FN fibril inhibition. On stiffer (8.5 kPa) pillars, FUD and Y27632 had similar effects.