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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: Trends Biochem Sci. 2015 Oct 21;40(11):628–647. doi: 10.1016/j.tibs.2015.09.002

Figure 8. Key figure.

Figure 8

Protein dynamics define communication lines inside the kinase core. (A) Two hydrophobic spines span the kinase core and connect major communities that are responsible for catalysis and regulation: A, C, D and F. (B) The amended central dogma of biology where the connection between protein structure and its function is mediated by protein dynamics. (C) The conserved αC-β4 Loop appears to be an important “communication hub” that connects Community A from the N-lobe to three C-lobe communities: Community D, which plays an important role in catalysis, regulatory Community C and Community E. It includes the two R-spine residues in the N-lobe (RS3 and RS4) and anchors them to the two R-spine residues from the C-lobe when the active conformation is assembled.