Table 1.

Effects of sulfhydration

Protein	Residues Sulfhydrated	Effect on Function	Reference
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH)	C150	Increases catalytic activity. In brain, increases association with the E3 ubiquitin ligase, Siah1 and targets PSD95 for degradation.	25,73
β-Actin	Not determined	Increased actin polymerization	25
Protein tyrosine phosphatase 1B (PTP1B)	C215	Reduces phosphatase activity	10
Kir6.1 subunit of KATP	C43	Activates channel activity by enhancing its interaction with PIP2	45
IKCa	Not determined	Activates channel	45
p65 subunit of NF-κB	C38	Promotes its interaction with the coactivator protein, ribosomal protein S3 (Rps3)	6
Parkin	C59, C95, C182	Enhances its E3 ubiquitin ligase activity	69
Keap1	C151	Promotes dissociation from the transcription factor Nrf2 and releases it from sequestration	64
MEK1	C341	Facilitates PARP activation	82
Cu/Zn superoxide dismutase	C111	Prevents oxidation induced aggregation	83
p66Shc	C59	Prevents H2O2-induced phosphorylation and generation of ROS	84
Androgen receptor	C611, C614	Prevents dimerization of the receptor	85
TRPV6	C172, C329	Maintains calcium homeostasis in bone marrow stem cells	86
PTEN	C71, C124	Maintains enzyme activity. Prevents further oxidation by nitric oxide	32
Interferon regulatory factor 1 (IRF1)	C53	Enhances the binding of the transcription factor (IS THAT WHAT YOU MEAN?) to the DNA methyl transferase 3A (DNMT3A) promoter to reduce methylation of target genes such as TFAM, a mitochondrial transcription factor, which is involved in mitochondrial biogenesis.	55