TABLE 1.
Comparison of Ovarian Morphology Measured by MRI in Adolescent Subjects with PCOS vs. Controls using Rotterdam, Lujan et al, and Current Study Criteria
| PCOS (N=39) | Controls (N=22) | p -value | |
|---|---|---|---|
| Number ovaries | 78 | 44 | |
| Median (IQR) OV(cm3) | 11.8 (6.9) | 7.0 (4.4) | <0.001 |
| Mean ± SD OV (cm3) | 13.6 ± 8.5 | 7.4 ± 3.4 | <0.001 |
| % (number) of ovaries with OV >10 cm3 (Rotterdam) | 65% (51) | 23% (10) | <0.001 |
| % (number) of ovaries with OV >14 cm3 (Kenigsberg et al) | 33% (26) | 5% (2) | <0.001 |
| Median (IQR) FNPS (2–9mm) | 12.0 (5.0) | 7.5 (5.0) | <0.001 |
| Mean±SD FNPS (2–9mm) | 12.7 ± 4.0 | 7.7 ± 4.4 | <0.001 |
| % (number) of ovaries with FNPS ≥12 (Rotterdam)a | 64% (50) | 18% (8) | <0.001 |
| % (number) of ovaries with FNPS ≥9 (Lujan et al) | 85% (66) | 41% (18) | <0.01 |
| % (number) of ovaries with FNPS ≥17 (Kenigsberg et al) | 17% (13) | 2% (1) | 0.01 |
| % (number) of ovaries with peripheral distribution of follicles | 62% (48) | 37% (15)b | 0.01 |
| % stromal area (stromal area/total area) | 51 ± 11.2 | 49 ± 14.3 | NS |
Data presented as median with interquartile range (IQR) or mean ± SD
a
Based on follicle count from Rotterdam criteria
b
Unable to evaluate on 3 ovaries thus denominator is 41 not 44
OV = Ovarian Volume; FNPS = Follicle Number Per Section