Table 2.

Treatment-Related Differences in Genes Suppressed during Infection

Gene name	Gene symbol	Infected vehicle	Anti-Ang2 antibody, %	Anti-TNF antibody, %	Antibody combination, %
Anti-Ang2 antibody: suppression of smaller expression increases during infection
Eph receptor A4	Epha4	1.3	−115	−180	−179
Fibulin 2	Fbln2	1.4	−70	−117	−128
Fibrillin 1	Fbn1	1.4	−51	−66	−77
Serpin B2	Serpinb2	1.5	−86	−4	−97
Follistatin	Fst	1.5	−72	−64	−100
Neurotensin	Nts	2.1	−77	−67	−81
Von Willebrand factor	Vwf	2.2	−58	−89	−111
Chemokine (C-C motif) receptor 2	Ccr2	2.3	−61	76	−27
Selectin, endothelial cell	Sele	4.7	−50	−70	−91
Prokineticin 2	Prok2	6.0	−74	−95	−96
Anti-TNF antibody and antibody combination: suppression of largest increases with infection
Selectin, platelet	Selp	16.6	−37	−74	−83
Pro-platelet basic protein	Ppbp	18.6	30	−80	−89
Colony-stimulating factor 3 receptor	Csf3r	19.5	13	−45	−74
Schlafen 1	Slfn1	19.7	18	−21	−57
Matrix metallopeptidase 8	Mmp8	20.3	−30	−83	−94
Matrix metallopeptidase 3	Mmp3	23.5	−5	−58	−63
Chemokine (C-C motif) receptor 1	Ccr1	24.2	−7	−24	−50
Chemokine (C-X-C motif) ligand 1	Cxcl1	26.2	−8	−46	−67
Formyl peptide receptor 1	Fpr1	27.9	0	−76	−93
Pleckstrin	Plek	31.9	5	−38	−67
Sclafen 3	Slfn3	49.9	10	−49	−83
Chemokine (C-X-C motif) ligand 10	Cxcl10	56.7	0	−38	−68
IL-1 receptor antagonist	Il1rn	60.0	6	−42	−77
Chemokine (C-C motif) ligand 3	Ccl3	68.6	28	−52	−82
Formyl peptide receptor 2	Fpr2	79.0	12	−59	−83
Chemokine (C-X-C motif) ligand 3	Cxcl3	83.6	−18	−79	−86
C-type lectin domain family 4d	Clec4d	87.8	10	−50	−80
C-type lectin domain family 4e	Clec4e	124.3	14	−50	−85
IL-1β	Il1b	127.9	2	−42	−75
Serum amyloid A3	Saa3	198.8	0	−64	−62
Schlafen 4	Slfn4	203.3	5	−51	−72
Immunoresponsive gene 1	Irg1	229.2	7	−53	−78
Chemokine (C-X-C motif) ligand 2	Cxcl2	280.5	4	−55	−75
S100 calcium binding protein A8	S100a8	282.7	−10	−61	−79
S100 calcium binding protein A9	S100a9	324.3	−8	−54	−78

Genes with the largest increases during Mycoplasma pulmonis infection (7 days; condition A) ranked by fold increase from pathogen free. Genes included had at least one treatment reduce expression by 50% or more. Treatment with anti-Ang2 antibody alone suppressed genes that underwent more modest increases after infection than with anti-TNF antibody or antibody combination. More negative values indicate greater suppression of the infection-induced increase in expression. A value of −100% indicates complete suppression of the increase, and values <−100% indicate suppression of expression to lower than the pathogen-free level.

Ang2, angiopoietin-2; TNF, tumor necrosis factor.