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Schematic view of the interactions between COX-1 (A), COX-2 (B), and PXM (Pyr1).
Notes: The two-dimensional depictions show hydrogen bonds as green dashed lines between the interaction partners on either side. Residues comprising the active sites and in proximity of the drug are shown. The ligand itself is drawn using the two-dimensional draw engine according to chemical drawing conventions.
Abbreviations: COX-1 and -2, cyclo-oxygenases-1 and 2; PXM, piroxicam.
