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. 2015 Oct 29;9:5843–5850. doi: 10.2147/DDDT.S84849

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© 2015 Campione et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Schematic representation of PXM effect on AK UVB irradiation-induced mutations on keratinocyte dysplasia and AK progression.

Notes: PXM inhibits COX-1 and COX-2 activity, with the downregulation of prostaglandin (PGH₂, PGE₂, PGI₂, and TXA₂) biosynthesis and the inhibition of the upregulated 15-PGDH. COX-1 and COX-2 activities are involved in skin tumor progression arrest and restoration of normal epidermal architecture (right).

Abbreviations: COX-1 and -2, cyclo-oxygenases-1 and 2; PXM, piroxicam; AK, actinic keratose; UVB, ultraviolet B; 15-PDGH, 15-hydroxy-prostaglandin dehydrogenase; PGH₂, prostaglandin H₂; PGE₂, prostaglandin E₂; PGII₂, prostaciclin; TXA2, tromboxan 2.