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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: JAMA Psychiatry. 2015 Jun;72(6):552–560. doi: 10.1001/jamapsychiatry.2014.3176

Figure 4. Hemispheric specialization is altered in subcortical and cortical networks associated with the caudate nucleus.

Figure 4

A. Due to the decreased left- and increased right-hemispheric caudate specialization, the difference between left and right AI values was significantly diminished in schizophrenia patients (gray bar) as compared to healthy controls (white bar) (p<0.0005).

B. This diminished difference between left- and right- hemispheric AI values could be replicated in caudate-connected cortical regions (p<0.01). The cortical mask was derived from a correlation analysis in 1000 healthy subjects, in which the caudate nucleus served as the seed region. Cortical AI values were averaged within the boundaries of this mask for each individual subject, and the individual mean values were averaged within each of the two groups.