Table 2.
Associations between HR and clinical and histopathological parameters
| Parameter | HR-positive (n = 6199) | HR-negative (n = 1030) | Total (n = 7229) | P valuea |
|---|---|---|---|---|
| Age (year), mean ± SD | 62 ± 13 | 57 ± 14 | 61 ± 13 | <0.001 |
| Menopausal state, n (%) | ||||
| Premenopausal | 1369 (22.1 %) | 315 (30.6 %) | 1684 (23.3 %) | <0.001 |
| Postmenopausal | 4830 (77.9 %) | 715 (69.4 %) | 5545 (76.7 %) | |
| Histology, n (%) | ||||
| Ductal | 4913 (79.3 %) | 896 (87.0 %) | 5809 (80.4 %) | <0.001 |
| Lobular | 876 (14.1 %) | 28 (2.7 %) | 904 (12.5 %) | |
| Other | 410 (6.6 %) | 106 (10.3 %) | 516 (7.1 %) | |
| Tumor size, n (%) | ||||
| pT0 | 27 (0.4 %) | 31 (3.0 %) | 58 (0.8 %) | <0.001 |
| pT1 | 3385 (54.6 %) | 435 (42.2 %) | 3820 (52.8 %) | |
| pT2 | 2217 (35.8 %) | 449 (43.6 %) | 2666 (36.9 %) | |
| pT3 | 237 (3.8 %) | 49 (4.8 %) | 286 (4.0 %) | |
| pT4 | 301 (4.9 %) | 56 (5.4 %) | 357 (4.9 %) | |
| Unknown | 32 (0.5 %) | 10 (1.0 %) | 42 (0.6 %) | |
| Nodal status, n (%) | ||||
| pN0 | 3832 (61.8 %) | 608 (59.0 %) | 4440 (61.4 %) | 0.032 |
| pN1 | 1534 (24.7 %) | 249 (24.2 %) | 1783 (24.7 %) | |
| pN2 | 425 (6.9 %) | 93 (9.0 %) | 518 (7.2 %) | |
| pN3 | 283 (4.6 %) | 57 (5.5 %) | 340 (4.7 %) | |
| Unknown | 125 (2.0 %) | 23 (2.2 %) | 148 (2.0 %) | |
| Grading, n (%) | ||||
| G1 | 1017 (16.4 %) | 14 (1.4 %) | 1031 (14.3 %) | <0.001 |
| G2 | 3891 (62.8 %) | 256 (24.9 %) | 4147 (57.4 %) | |
| G3 | 1252 (20.2 %) | 752 (73.0 %) | 2004 (27.7 %) | |
| Unknown | 39 (0.6 %) | 8 (0.8 %) | 47 (0.7 %) | |
| HER2, n (%) | ||||
| Negative | 4678 (75.5 %) | 624 (60.6 %) | 5302 (73.3 %) | <0.001 |
| Positive | 952 (15.4 %) | 306 (29.7 %) | 1258 (17.4 %) | |
| Unknown | 569 (9.2 %) | 100 (9.7 %) | 669 (9.3 %) | |
| Lymphatic invasion, n (%) | ||||
| Positive | 1676 (27.0 %) | 350 (34.0 %) | 2026 (28.0 %) | <0.001 |
| Negative | 3024 (48.8 %) | 430 (41.7 %) | 3454 (47.8 %) | |
| Unknown | 1499 (24.2 %) | 250 (24.3 %) | 1749 (24.2 %) | |
| Vascular invasion, n (%) | ||||
| Positive | 320 (5.2 %) | 92 (8.9 %) | 412 (5.7 %) | <0.001 |
| Negative | 4168 (67.2 %) | 634 (61.6 %) | 4802 (66.4 %) | |
| Unknown | 1711 (27.6 %) | 304 (29.5 %) | 2015 (27.9 %) | |
HR-positive is defined as ER+PR+, ER+PR−, or ER−PR+
HR-negative is defined as ER−PR−
a P value of t test or Pearson’s Chi-square test, respectively