Table 7.
Multivariable Cox proportional hazard model on overall survival
| Characteristic | Overall survival (n = 5410, events = 705) | ||
|---|---|---|---|
| HR | 95 % CI | P value | |
| Primary therapy | |||
| CHT + ET + Trastuzumab | Reference | ||
| CHT + ET | 1.68 | 0.89, 3.15 | 0.109 |
| ET | 2.14 | 1.13, 4.06 | 0.019 |
| CHT | 4.54 | 2.29, 9.00 | <0.001 |
| No adjuvant therapy | 4.69 | 2.43, 9.06 | <0.001 |
| Age (years) | 1.05 | 1.04, 1.06 | <0.001 |
| Tumor size | |||
| pT1 | Reference | ||
| pT2 | 1.53 | 1.27, 1.84 | <0.001 |
| pT3 | 2.06 | 1.49, 2.85 | <0.001 |
| pT4 | 2.51 | 1.92, 3.27 | <0.001 |
| Nodal status | |||
| N0 | Reference | ||
| N1 | 1.55 | 1.29, 1.87 | <0.001 |
| N2 | 1.90 | 1.46, 2.48 | <0.001 |
| N3 | 2.69 | 2.04, 3.55 | <0.001 |
| Grading | |||
| G1 | Reference | ||
| G2 | 1.29 | 0.99, 1.68 | 0.063 |
| G3 | 2.00 | 1.49, 2.68 | <0.001 |
| HER2/neu | |||
| Negative | Reference | ||
| Positive | 1.00 | 0.81, 1.23 | 0.986 |
| Menopausal status | |||
| Premenopausal | Reference | ||
| Postmenopausal | 0.67 | 0.48, 0.92 | 0.012 |