Table 1.
Patient characteristics
| Characteristics | Patients who did not receive bolus infusion of hydrocortisone (N = 5447) | Patients who received bolus infusion of hydrocortisone (N = 962) | P value | Total cohort (N = 6409) |
|---|---|---|---|---|
| Age (years, median [IQR]) | 63 [51–73] | 65 [55–74] | <0.001 | 63 [52–73] |
| Male gender [no (%)] | 3431 (63.0) | 571 (59.4) | 0.035 | 4002 (62.4) |
| BMI (kg/m2, median [IQR]) | 25 [23–28] | 25 [23–29] | 0.968 | 25 [23–28] |
| Admission diagnosis [no (%)] | <0.001 | |||
| Non-surgical | 2159 (39.6) | 542 (56.3) | 2701 (42.1) | |
| Emergency surgery | 993 (18.2) | 200 (20.8) | 1193 (18.6) | |
| Elective surgery | 2295 (42.1) | 220 (22.9) | 2515 (39.2) | |
| History of diabetes [no (%)] | ||||
| Diabetes | 550 (14.7) | 102 (16.5) | 0.281 | 652 (15.0) |
| Non diabetes | 3188 (85.3) | 517 (83.5) | 3705 (85.0) | |
| Missing values | 1709 | 343 | 2052 | |
| APACHE II scores (median [IQR]) | 18 [14–24} | 24 [19–30] | <0.001 | 19 [14–25] |
| SAPS II score | 40 [31–52] | 55 [44–67] | <0.001 | 42 [32–54] |
| ICU LOS (days, median [IQR]) | 2 [1–4] | 6 [3–12] | <0.001 | 3 [2–5] |
| Hospital LOS (days, median [IQR]) | 10 [6–20] | 16 [8–36] | <0.001 | 11 [6–22] |
| ICU mortality [no (%)] | 658 (12.1) | 306 (31.8) | <0.001 | 961 (15.0) |
| Hospital mortality [no (%)] | 944 (17.3) | 391 (40.6) | <0.001 | 1335 (20.8) |
APACHE acute physiology and chronic health evaluation, BMI body mass index, ICU intensive care unit, IQR interquartile range, LOS length of stay