Table 2.
Blood glucose metrics
| Patients who did not receive bolus infusion of hydrocortisone (N = 5447) | Patients who received bolus infusion of hydrocortisone (N = 962) | P value | Total cohort (N = 6409) | |
|---|---|---|---|---|
| Number of measurements (median [IQR]) | 20 [13–35] | 53 [30–97] | <0.001 | 22 [13–42] |
| Median number of measurements per day (median [IQR]) | 6 [5–8] | 7 [6–9] | <0.001 | 6 [5–8] |
| Median number of measurements per day with hydrocortisone (median [IQR]) | 8 [7–10] | |||
| Median number of measurements per day without hydrocortisone (median [IQR]) | 6 [4–7] | |||
| Mean blood glucose level (mg/dL, median [IQR]) | 136 [125–148] | 136 [127–148] | 0.043 | 136 [126–148] |
| Median blood glucose level (mg/dL, median [IQR]) | 132 [122–144] | 132 [123–141] | 0.588 | 132 [123–144] |
| Standard deviation of blood glucose level (mg/dL, median [IQR]) | 28 [20–39] | 35 [26–47] | <0.001 | 29 [21–40] |
| Glycemic Lability Index (mg/dL2/hour/day median [IQR]) | 942 [371–2236] | 1322 [594–2883] | <0.001 | 994 [400–2369] |
| Maximum blood glucose level (mg/dL, median [IQR]) | 193 [166–234] | 231 [193–285] | <0.001 | 198 [169–241] |
| Minimum blood glucose level (mg/dL, median [IQR]) | 90 [77–101] | 70 [56–85] | <0.001 | 88 [74–99] |
| Mild hypoglycemia, <70 mg/dL (%) | 826 (15.2) | 451 (46.9) | <0.001 | 1277 (19.9) |
| Severe hypoglycemia, <40 mg/dL (%) | 115 (2.1) | 80 (8.3) | <0.001 | 195 (3.0) |
| Hyperglycemia, >180 mg/dL (%) | 3438 (63.1) | 824 (85.7) | <0.001 | 4262 (66.5) |
IQR interquartile range, IU international units