(b).
| SD vaccine recipients | HD vaccine recipients | |||||
|---|---|---|---|---|---|---|
| Nonobese | Obese | p value | Nonobese | Obese | p value | |
| n = 64 | n = 21 | n = 64 | n = 27 | |||
| Seroconversion, % (95% CI) | ||||||
| H1N1 | 59 (47–72) | 62 (39–84) | 0.84 | 81 (71–91) | 63 (43–82) | 0.06 |
| H3N2 | 75 (64–86) | 71 (50–92) | 0.74 | 78 (68–88) | 85 (71–100) | 0.44 |
| Influenza B | 34 (22–46) | 29 (8–50) | 0.62 | 53 (40–66) | 63 (43–82) | 0.39 |
| Seroprotection, % (95% CI) | ||||||
| H1N1 | 86 (77–95) | 90 (77–100) | 0.59 | 98 (95–100) | 89 (76–100) | 0.04 |
| H3N2 | 91 (83–98) | 100 (100–100) | 0.15 | 97 (92–100) | 93 (82–100) | 0.36 |
| Influenza B | 83 (73–92) | 67 (45–89) | 0.12 | 89 (81–97) | 96 (89–100) | 0.27 |
| Prevaccination GMT (95% CI) | ||||||
| H1N1 | 20 (11–37) | 22 (7–67) | 0.90 | 17 (9–30) | 59 (23–154) | 0.02 |
| H3N2 | 33 (20–55) | 17 (6–48) | 0.20 | 24 (13–43) | 23 (10–54) | 0.97 |
| Influenza B | 16 (10–26) | 18 (8–38) | 0.84 | 18 (11–30) | 20 (11–37) | 0.86 |
| Postvaccination GMT (95% CI) | ||||||
| H1N1 | 307 (180–524) | 386 (178–839) | 0.66 | 684 (489–955) | 746 (356–1570) | 0.82 |
| H3N2 | 322 (202–515) | 338 (192–667) | 0.92 | 681 (439–1057) | 771 (409–1456) | 0.75 |
| Influenza B | 63 (42–93) | 60 (25–144) | 0.92 | 149 (109–204) | 122 (78–192) | 0.48 |
BMI: body mass index; CI: confidence interval; GMT: geometric mean titer; HD: high dose; SD: standard dose.