Table 3.
Mean levels of brain oxidative stress and proinflammatory parameters in control, NASH, and berberine treated groups.
| Groups | TBARS (nM/mL) |
XO (µM/hour) | GPx (IU) |
SOD (IU) |
GSH (mg/dL) | TNF-alpha (pg/L) | NO (nmole/mL) |
|---|---|---|---|---|---|---|---|
| Control | 12.5 ± 1.2a | 8.2 ± 0.9a | 0.02 ± 0.001b | 8.2 ± 0.07c | 21 ± 2.1b | 60.5 ± 3.5b | 5.6 ± 0.5a |
| Berberine control | 10.1 ± 2.1a | 7.5 ± 0.4a | 0.02 ± 0.001b | 9.9 ± 0.5d | 34 ± 2.3c | 50.4 ± 6.2a | 4.3 ± 0.6a |
| NASH group | 30.5 ± 3.1c | 12.3 ± 0.6c | 0.01 ± 0.007a | 2.1 ± 0.04a | 6.4 ± 0.7a | 205 ± 12.5c | 54.1 ± 2d |
| Berberine treatment | 14.6 ± 1.9ab | 10.1 ± 0.9b | 0.019 ± 0.0001b | 7.3 ± 0.2b | 20.1 ± 0.65b | 89 ± 10.1c | 11.5 ± 1c |
Values are reported as means ± SD of rat groups with different degrees of significance at P < 0.05.
aLowest value of significance.
dHighest value of significance.
If two groups have the same letters, it means no significant difference is detected.