Table 3. List of studies evaluating EGFR gene activating and resistance mutations and their level modification.
| First author | Year | Methodic | No. of patients | EGFR determination | EGFR variation levels | T790M determination (timing) | T790M variation levels | Others |
|---|---|---|---|---|---|---|---|---|
| Murtaza M (36) | 2013 | Digital PCR | 1 | √ | √ | √ (R) | √ | p53, NFKB1 |
| Oxnard GR (81) | 2014 | dd-PCR | 9 | √ | √ | √ (R) | √ | – |
| Sorensen BS (82) | 2014 | Cobas EGFR blood test | 23 | √ | √ | √ (R) | √ | – |
| Marchetti A (83) | 2015 | Cobas EGFR blood test | 57 | √ | √ | – | – | – |
| Ahn MJ (84) | 2015 | dd-PCR | 60 | √ | √ | √ (R) | – | – |
| Wang Z (85) | 2014 | Digital PCR, ARMS | 135 | – | – | √ (D) | √ | – |
| Nakamura T (86) | 2011 | MBP-PQ | 49 | – | – | √ (R) | √ | – |
| Marcq M (87) | 2014 | ARMS | 2 | √ | √ | √ (R) | √ | – |
| Piotrowska Z (88) | 2015 | BEAMing | 12 | √ | √ | √ (R) | √ | – |
| Sequist LV (89) | 2015 | BEAMIing | 113 | – | – | √ (R) | √ | – |
| Thress KS (90) | 2015 | NGS, dd-PCR | 19 | √ | √ | √ (R) | √ | EGFR C797S |
dd-PCR, digital droplet-PCR; ARMS, amplification refractory mutation system; MBP-PQ, mutation-biased PCR quenching probe; BEAMing, beads, emulsion, amplification and magnetics; (R), at resistance; (D), at first diagnosis.