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MTM1 mutation in dogs results in progressive loss of limb muscle strength in the first 4 months of life. (A) In vivo maximal isometric torque measured in forelimb extensor muscles (mainly the extensor carpi radialis) and (B) in vivo maximal isometric torque measured in hindlimb flexor muscles (mainly the cranial tibialis). Control dogs (WT and carriers) are shown in black; XLMTM dogs in red. XLMTM, X-linked myotubular myopathy.
