Table 4. Ventilatory parameters under doxapram (1 mg/kg) stimulation measured in normal and XLMTM dogs at 10, 17 and 25 weeks-of-age.
| Dog | Inspiratory time (ms) | Expiratory time (ms) | Peak inspiratory flow (mL/s) | Peak expiratory flow (mL/s) | Tidal volume (mL/kg) | Expiratory volume (mL/kg) | Minute ventilation (mL/s/kg) | Respiratory rate (bpm) |
|---|---|---|---|---|---|---|---|---|
| Normal | ||||||||
| 10 weeks (n=6) | 399.6±97 | 394.2±209 | 247.3±63 | 364.8±46 | 12.1±4 | 12.4±2 | 1,001.8±477 | 78.5±22 |
| 17 weeks (n=6) | 538.7±86 | 572.5±160 | 343.8±76 | 571.8±93 | 16.4±3 | 16.2±3 | 954.8±245 | 58.7±12 |
| 25 weeks (n=6) | 791.0±217 | 731.8±192 | 407.4±65 | 668.0±106 | 19.6±2 | 20.0±2 | 823.6±166 | 42.3±10 |
| XLMTM | ||||||||
| 10 weeks (n=6) | 439.1±101 | 589.0±252 | 224.1±79 | 286.9±115 | 13.4±2 | 12.5±3 | 865.6±253 | 65.4±22 |
| 17 weeks (n=3) | 772.6±319 | 760.9±260 | 268.9±78.2 | 418.7±133 | 16.8±8 | 16.4±8 | 675.0±262 | 40.0±16 |
| 21 weeks (n=2) | 1,542 | 907.5 | 458.0 | 602.6 | 24.6 | 21.8 | 654.5 | 27.0 |
Data are presented as mean ± SD. XLMTM, X-linked myotubular myopathy.