Figure 1. DADS significantly attenuates radiation-induced morphological damage in mouse testis.

(A) Chemical structure of DADS. (B) Representative HE-stained histological sections of mouse testis treated with DADS (10 mg/kg, 20 mg/kg, and 40 mg/kg) and/or 4 Gy carbon ion irradiation. Seminiferous epithelium was thinner (yellow line) and cavities were formed in the seminiferous epithelium (dotted line circle) leading to hollow seminiferous tubules. Spermatogenic cells were disarranged and the spermatogonia should be close to the basement membrane. The basement membranes (arrow) were destroyed and disrupted (bracket). HE staining was performed at 40× magnification.