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. 2015 Nov 3;5:16089. doi: 10.1038/srep16089

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On saggital section, it shows that TRBx is performed in three planes of prostate (base, middle and apex plane). The depots of PPNB are apical (in the white circle with diagonals), and the routes of administration are transrectal (white dotted lines). On transverse section, it shows the protocol of biopsy in each plane (two parasagittal biopsies and two far-lateral biopsies). Four cores are sampled in base plane and four in apex planes respectively for 8-core TRBx, and another four cores are sampled in middle plane for 12-core TRBx.