Table 1.
Baseline demographics, clinical data, and amino acid parameters of patients.
| n | 25 |
| Age [years] | 69 ± 14 |
| Male/female | 14/11 |
| Body weight [kg] | 80 (13) |
| Source of sepsis | |
| Lung | 13 |
| Kidney | 2 |
| Burned skin | 7 |
| Wound | 1 |
| Abdomen | 2 |
| APACHE II | 16 (10) |
| MODS | 5 (5) |
| SAPS II | 37.5 (20) |
| Serum creatinine [µmol/L] | 118 95.5 |
| hsCRP [mg/L] | 154.2 ± 92.8 |
| PCT [ng/mL] | 7.62 19.23 |
| Daily urine output [mL] | 2055 (1775) |
| Mean daily glucose [mmol/L] | 9.0 2.5 |
| DID [U/day] | 19 (25) |
| IGP [U∗mmol/L] | 183.4223 261.2992 |
| Number of patients receiving hydrocortisone | 18 (72%) |
| Daily hydrocortisone dose [mg/day] | 200 (100) |
| Number of patients receiving dobutamine | 10 (40%) |
| Daily dobutamine dose [mg/day] | 275.0 537.5 |
| Serum p-Tyr [µmol/L] | 45.177 ± 18.049 |
| Serum m-Tyr [nmol/L] | 14 (27) |
| Serum o-Tyr [nmol/L] | 14 (15) |
| Serum Phe [µmol/L] | 65.374 ± 27.519 |
| Serum p-Tyr/Phe [µmol/µmol] | 0.654 0.292 |
| Serum m-Tyr/Phe [nmol/µmol] | 0.2 0.4 |
| Serum o-Tyr/Phe [nmol/µmol] | 0.2 0.4 |
| Serum m-Tyr/p-Tyr [nmol/µmol] | 0.3 0.5 |
| Serum o-Tyr/p-Tyr [nmol/µmol] | 0.3 0.5 |
| Serum (m-Tyr+o-Tyr)/Phe [nmol/µmol] | 0.5 0.7 |
| Serum (m-Tyr+o-Tyr)/p-Tyr [nmol/µmol] | 0.6 1.1 |
| Urinary p-Tyr [µmol/L] | 25.394 44.402 |
| Urinary m-Tyr [nmol/L] | 123 (351) |
| Urinary o-Tyr [nmol/L] | 194 (661) |
| Urinary m-Tyr/p-Tyr [nmol/µmol] | 4 (17) |
| Urinary o-Tyr/p-Tyr [nmol/µmol] | 9 (39) |
| Urinary (m-Tyr+o-Tyr)/p-Tyr [nmol/µmol] | 21 (85) |
| Urinary p-Tyr/creatinine [µmol/mmol] | 6.952 11.645 |
| Urinary m-Tyr/creatinine [nmol/mmol] | 29 (68) |
| Urinary o-Tyr/creatinine [nmol/mmol] | 61 (220) |
| Daily excretion of p-Tyr [µmol/day] | 56.268 116.710 |
| Daily excretion of m-Tyr [nmol/day] | 259 (607) |
| Daily excretion of o-Tyr [nmol/day] | 304 (1786) |
| Clearance of p-Tyr [mL/min] | 0.605 1.720 |
| Clearance of m-Tyr [mL/min] | 9.011 27.413* |
| Clearance of o-Tyr [mL/min] | 17.198 105.512∗† |
| FEp-Tyr [%] | 1.783 2.160 |
| FEm-Tyr [%] | 25.104 54.305‡ |
| FEo-Tyr [%] | 85.645 639.219ठ|
* P < 0.001 versus clearance of p-Tyr; † P = 0.019 versus clearance of m-Tyr; ‡ P < 0.001 versus FEp-Tyr; § P = 0.006 vs. FEm-Tyr.
APACHE II, acute physiology and chronic health evaluation II; MODS, multiple organ dysfunction score; SAPS II, simplified acute physiology score II; DID, daily insulin dose; IGP, insulin-glucose product; FE, fractional excretion.
Data expressed as mean ± SD or median (interquartile range).